Section 19 · Monograph
Bisacodyl
Reviewed Nov 2026FDA label
DulcolaxStimulant laxative
- Forms
- Tab: 5mg | Supp: 10mg
- Dose
- Constipation: 5-15mg PO daily, or 10mg PR daily for neurogenic bowel programs
- MOA
- Stimulates enteric neurons and colonic secretion
Indications
- Constipation and bowel preparation (OTC); bowel programs in neurogenic bowelFDA-labeled
Mechanism of Action
- Stimulant laxative acting on enteric neurons to increase colonic motility and fluid secretion
Full Dosing
Adult / usual
- PO: 5-15mg once daily; PR: 10mg suppository once daily or as part of a scheduled neurogenic bowel program
- Do not crush or chew enteric-coated tablets; do not give with antacids or milk within 1 hour
- Oral onset 6-12 hours; rectal 15-60 minutes
Contraindications
- Intestinal obstruction, acute abdomen, ileus
- Severe dehydration; hypersensitivity
Drug Interactions
- Antacids and milk can dissolve the enteric coating
- Diuretics and corticosteroids: additive electrolyte loss
Adverse Effects
- Abdominal cramping
- Diarrhea and electrolyte disturbance
- Rectal irritation with suppositories
Monitoring Parameters
- Bowel pattern
- Hydration and electrolytes with prolonged use
Pregnancy & Lactation
- Generally considered acceptable when needed
- Minimal transfer into milk