Section 11
Vertigo & Vestibular
Dizziness, Nausea & Vestibular Agents
5 AGENTS
Meclizine
AntivertH1 antihistamine
- Forms
- Tab: 12.5, 25, 50mg
- Dose
- 25-100mg/day divided
- MOA
- Central anticholinergic/antihistamine, ↓vestibular activity
Dimenhydrinate
DramamineH1 antihistamine
- Forms
- Tab: 50mg | Chew: 50mg
- Dose
- 50-100mg q4-6h (max 400mg/day)
- MOA
- H1/muscarinic blockade, antiemetic
Scopolamine
Transderm ScopAnticholinergic · patch
- Forms
- Patch: 1.5mg/72h
- Dose
- 1 patch behind ear every 72h
- MOA
- Muscarinic receptor blockade
Promethazine
PhenerganPhenothiazine antihistamine
- Forms
- Tab: 12.5, 25, 50mg | Supp: 12.5, 25, 50mg | IM/IV: 25mg/mL
- Dose
- 12.5-25mg q4-6h PRN
- MOA
- H1/D2/muscarinic blockade
Ondansetron
Zofran5-HT3 antagonist
- Forms
- Tab: 4, 8mg | ODT: 4, 8mg | IV: 2mg/mL
- Dose
- 4-8mg q8h PRN
- MOA
- Blocks 5-HT3 receptors (antiemetic)