Section 20
Hyperkinetic Movement Disorders
VMAT2 inhibitors
3 AGENTS
Tetrabenazine
XenazineVMAT2 inhibitor
- Forms
- Tab: 12.5, 25mg
- Dose
- titrate to 25-75mg/day
- MOA
- Depletes presynaptic dopamine/serotonin/NE
Deutetrabenazine
Austedo, Austedo XRVMAT2 inhibitor
- Forms
- Tab: 6, 9, 12, 18, 24mg
- Dose
- titrate to 12-48mg/day divided
- MOA
- Depletes presynaptic monoamines
Valbenazine
IngrezzaVMAT2 inhibitor
- Forms
- Cap: 40, 60, 80mg
- Dose
- 40-80mg once daily
- MOA
- Depletes presynaptic dopamine